Adam, Isabell; Dewi, Dyah L.; Mooiweer, Joram; Sadik, Ahmed; Mohapatra, Soumya R.; Berdel, Bianca; Keil, Melanie; Sonner, Jana K.; Thedieck, Kathrin; Rose, Adam J.; Platten, Michael; Heiland, Ines; Trump, Saskia; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-05)
Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful
immunosuppressive mechanism hijacked by tumors for protection against immune destruction.
However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid
Trp. Trp is incorporated into proteins after it is attached to its tRNA by tryptophanyl-tRNA synthestases.
As ...